|
The present study is based on clinicopathological data of 43 retinoblastoma cases collected consecutively and diagnosed pathologically within a period from 1964 to 1981. The main conclusions to be drawn from this study are as follows. 1 Both sexes were almost equally affected. 2. The average age of initial diagnosis was fiund to be 2.9 years. The youngest was aged 3 months and the oldest 7 years. 38 of the cases(88.9%) had been diagnosed before the age of 5 years and 6 of the cases(14.0%) before the age of 2 years. 3. The most common initial sign was a white pupillary reflex(32 cases, 74%) 4. In gross findings, about two-thirds of the cases(65.1%) had the tumor size greater than a half of a globe at the time of ucleation. 5. Determination of the macroscopic growth pattern was impossible about in two-thirds of the cases(65.1%). And 11 of casses(25.6%) showed multicentric growth, which suggested the tendency of this neoplasm to have multicentric orgin in the retina. 6. Histopathologica characteristics revealed that 24 of the cases(55.8%) showed undifferentiated cells, 15 of the cases(34.9%) rosettes, and 4 of the cases(9.3%)fleurettes. Additionally, tumor nesrosis 15 of the cases(62.8%), calcification(51.2%) and hemorrhages(44.2%) were observed frequently. 7. In mode of extension, invasion of the vitreous occurred most commonly in 31 of the cases(72.1%), and choroidal invasion in 14 of the cases(32.6%). 8. A misdiagnosis rate was 17.3%; among 52 cases with clinically suspected retinoblastoma, 9 of the cases were proved by microscopic examination to have some other pathologic condition.
|